Zyprexa Warnings over Weight Gain, Blood Sugar Elevation

April 3rd, 2008 Blood Sugar Posted in Blood Sugar, a1c, average blood sugar level, bitter melon, blood glucose, blood glucose level, blood glucose meter, blood glucose monitoring, blood glucose monitors, blood glucose test, blood glucose test, blood sugar control, blood sugar level, blood sugar level chart, blood sugar levels, blood sugar meters, blood sugar meters, blood sugar monitor, blood sugar monitors, blood sugar problems, blood sugar range, blood sugar readings, blood sugar test, blood sugar tester, blood sugar testing, blood suger, cholesterol, controlling blood sugar, diabetes blood sugar, diabetes blood sugar levels, diabetes information, diabetes supplements, diabetic blood sugar, diabetic food, diabetic products, diabetic supplies, diabetics, elevated blood sugar, fasting blood glucose, fasting blood sugar, glucometer, glucose control, glucose diabetes, glucose monitoring, glycemic, glycemic index, greatest vitamin, healthy blood sugar level, heart disease, high blood glucose, high blood sugar, high blood sugar levels, high blood sugar symptoms, how to lower blood sugar, hyperglycemia, hypoglycemia, insulin, low blood sugar, low blood sugar symptoms, lower blood sugar, lowering blood sugar, natural sugar substitute, normal blood glucose, normal blood glucose levels, normal blood sugar, normal blood sugar, normal blood sugar level, normal blood sugar levels, reduce blood sugar, reducing blood sugar, safe blood sugar levels, sugar diabetes, sugar levels in blood, sugar substitute, sugar substitutes, symptoms of low blood sugar, vitamin supplement, vitamins, weight loss, whole food vitamins, whole vitamins Comments Off

 Eli Lilly and Company has announced changes to the labeling of Zyprexa and Symbyax, two brand-name atypical antipsychotics produced and sold by the company. Eli Lilly has updated the labeling to include more warning information on potentially harmful weight gain and blood sugar elevation that may result from taking the medications.

According to Eli Lilly, the label changes came about because of conversations with the FDA, as well as new analyses of the data from large clinical trials conducted by the company and others. The company will be sending a “Dear Healthcare Practitioner” letter to doctors about the new labeling, as well as informing consumer advocacy and professional associations.

Zyprexa is the brand name for olanzapine, while Symbyax is a mix of olanzapine and fluoxetine. Zyprexa is approved for use in treatment of schizophrenia and the mixed and manic portions of bipolar disorder, while Symbyax is approved for the treatment of bipolar depression.

Neither product is approved for patients with dementia, and they may increase the risk of death if used on elderly dementia patients. Nevertheless, in the past the company has marketed Zyprexa for treatment of dementia and for manic bipolar episodes.

One of the labeling changes focuses on unnatural weight gain from olanzapine. According to the company, the drug has been shown to lead to “significant and sometimes very high elevations in triglyceride levels.”

The other major change is a stronger emphasis on the drug’s effect on blood glucose levels. According to the company, atypical antipsychotics in general may lead to an increase in blood sugar levels, while olanzapine has an even greater effect than other such drugs. In some cases, patients treated with such medications have suffered complications including ketoacidosis, coma and even death.

In January, Eli Lilly settled 18,000 lawsuits from patients who alleged that using Zyprexa caused them to develop diabetes or other diseases. The company agreed to pay $500 million, bringing its total Zyprexa-related settlement costs to $1.2 billion.

AddThis Social Bookmark Button